A hypothetical model is suggested which represents the integral wholeness of a personality's structure and individuality proceeding from the position of unity of the innate and the acquired, of the natural and the social. The community of such substructures as motivation, temperament, abilities, and character has been established as well as their correlations with the fundamental personality trend. Both the wholeness and the community are determined by two-way real links between the substructures mediated by systemic factors: emotionality, activity, self-regulation, and drives. Most global natural prerequisites of motivation, temperament, abilities, and character are presented, and some prospective lines of analytical study of them by differential-psychological and psychophysiological means are outlined.